Cellistem®ER is an advanced therapy developed by Cells for Cells with allogeneic umbilical cord mesenchymal stem cells for regenerative endodontic procedures in mature teeth with apical lesions.

It is the first clinical study of safety and efficacy of the endodontic use of allogeneic mesenchymal stem cells from the umbilical cord encapsulated in a plasma-derived biomaterial.

The trial included 36 patients with mature mandibular incisors, canines, or premolars who had pulp necrosis and apical periodontitis.  

No adverse events were recorded and all patients showed clinical success.

UC-MSCs encapsulated in a PPP matrix are safe, effective and represent an innovative alternative treatment based on biological principles that promote dentin-pulp regeneration and periapical tissue health.


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