An advanced bio-ink based on a cold-adapted biomaterial (Salmon GelMA) with excellent mechanical and rheological properties for high-resolution 3D bioprinting.
Double compatibility with cells (mesenchymal stem cells, chondrocytes, etc.) and with 3D printing methods, such as inkjet.
Low viscosity in solution.
Stability in liquid state at room temperature, unlike mammalian GelMA.
Most advantageous for adjusting the extracellular matrix remodeling rate versus mammalian GelMA.
Young's modulus similar to that of bovine GelMa
Greater capacity for cell remodeling in vitro and in vivo compared to bovine GelMA due to the unique characteristics of cold-adapted biomaterials, such as reduced activation energy of collagenase, increased turnover of enzymatic hydrolysis, increased of the molecular mobility of the interconnected polypeptides and the lowest gel point